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Cover: a clear conditioned-media serum vial on white

EHL-Stem conditioned media: the real data on brightening and wrinkles

An INCI-registered cosmetic ingredient from EHL Bio

Quick answer

Stem cell conditioned media is the fluid produced while culturing stem cells, containing growth factors, cytokines, fibronectin and collagen. EHL Bio's EHL-Stem is INCI-registered as Human Adipose Stromal Cell Conditioned Media. Independent laboratory testing (Dermapro, January 2016) reported a 49% reduction in melanin production, 45% inhibition of tyrosinase and roughly a 9-fold increase in intracellular collagen synthesis.

Key facts

INCI name
Human Adipose Stromal Cell Conditioned Media
Application no.
5-09-2014-2745
Melanin reduction
49% (in vitro, Dermapro 2016)
Collagen increase
3.69 → 33.32 mg/g (~9x)
Key growth factors
VEGF, FGF, TGF, PDGF, HGF, EGF

What in-vitro numbers really mean

Those figures come from cell-level (in vitro) assays, not randomised controlled human application trials, so read them as ingredient potential rather than a promise that every finished product containing it performs identically.

Growth factors identified in EHL-Stem

Analysed components in EHL-Stem include VEGF, FGF, TGF, PDGF, HGF and EGF — growth factors tied to angiogenesis, tissue repair and fibroblast stimulation.

Safety criteria for conditioned media

On safety, the company states it uses only conditioned media meeting Korea's MFDS safety criteria, with safety studies run with GLP-accredited Biotoxtech, and formulations free of parabens, alcohol and colourants.

The bottom line for Thai consumers

Bottom line for Thai consumers: conditioned media is a topical cosmetic ingredient, not a disease treatment. If you see claims that injected conditioned media treats disease, check its legal status carefully.

Frequently asked questions

  • Does conditioned media contain cells?

    No. Cells are filtered out, leaving only the factors they secreted.

  • How long until visible results?

    Hydration can improve quickly, but wrinkle and brightness changes usually need 8-12 weeks of consistent use, in line with skin turnover.

  • Is it suitable for sensitive skin?

    Paraben-, alcohol- and fragrance-free formulas are usually low irritation, but patch-test on the inner arm for 48 hours before facial use.

  • How does it differ from ordinary growth factor serums?

    Source. Conditioned media is a natural multi-factor mixture from actual culture, whereas some serums add just one recombinant growth factor.

Medical cautions

5 points • reviewed 2026-08-28

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  • This article is educational information only — not a diagnosis, prescription, or personal medical advice.
  • Outcomes vary by person, depending on age, underlying conditions, current medication, and the treating doctor's technique.
  • Consult a licensed physician and verify the clinic's licence before deciding on any treatment.
  • Some treatments (certain stem cell therapies in particular) are regulated differently by country — check Thai and Korean rules before travelling.
  • Prices, packages, and service details can change — confirm directly with the provider before paying.

Reviewed and last updated: 2026-08-28

References and sources

10 sources • every claim is traceable

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  1. 1. EHL Bio — company introduction

    https://www.ehlbio.co.kr/company/about/

  2. 2. EHL Bio — company history

    https://www.ehlbio.co.kr/company/history/

  3. 3. EHL Bio — GMP centre

    https://www.ehlbio.co.kr/rd/gmp/

  4. 4. EHL Bio — stem cell therapeutics pipeline

    https://www.ehlbio.co.kr/rd/institute/

  5. 5. EHL Bio — patents and research papers

    https://www.ehlbio.co.kr/rd/patent/

  6. 6. EHL Bio — EHL-STEM conditioned media

    https://www.ehlbio.co.kr/conditioned/

  7. 7. EHL Bio — immune cells

    https://www.ehlbio.co.kr/immune_cell/

  8. 8. EHL Bio — target diseases

    https://www.ehlbio.co.kr/cure/index/

  9. 9. EHL Bio — locations and contact

    https://www.ehlbio.co.kr/company/contact/

  10. 10. Korea Ministry of Food and Drug Safety (MFDS)

    https://www.mfds.go.kr/eng/index.do

Browse the full reference library →

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Last updated: 2026-08-28 · This content is for information only and is not medical advice. Consult a qualified doctor before making treatment decisions.

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