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What is a secretome, and why does EUPOTON use an O₂ plasma secretome?

The signals cells release and their role in regenerative medicine

Quick answer

A secretome is the set of molecules cells release — growth factors, cytokines and signalling proteins. In EUPOTON, stage 5 is the O₂ secretome: the patient's own oxygen-activated plasma is infused with the activated cells to deliver repair signals to the body's cells.

Key facts

Protocol stage
Stage 5: O₂ secretome
High factors in deck
Angiogenin, G-CSF, PlGF, VEGF
Source
Manufacturer presentation, NUMATRON (EUPOTON)
Clinical use
Subject to local approval and physician judgment

In regenerative research, many groups suspect that part of stem cells' benefit comes from what they secrete (the paracrine effect) rather than the cells themselves, which is why secretomes get so much attention.

EUPOTON's manufacturer lays out the mechanism: source = activated blood; signal = stem cells + growth factors + secretome; response = homeostasis + recovery signals → restart, with cell identity kept.

The deck shows a growth-factor profile with high levels of angiogenin, G-CSF, PlGF and VEGF — factors linked to vessel formation and repair. This is lab data.

Note: this article summarises the manufacturer's materials. Lab figures are in-vitro results, not human treatment outcomes, and nothing here is medical advice. Clinical use follows local approvals and physician judgment. For the overview, see What is EUPOTON.

Frequently asked questions

  • How does a secretome differ from exosomes?

    A secretome is everything a cell releases; exosomes are one type of small vesicle within it.

  • Whose secretome is it?

    The patient's own plasma.

  • How does it work?

    It signals the body's cells to mount repair responses, per the manufacturer's mechanism.

  • Do cells change type?

    The manufacturer states cell identity is kept.

  • Does EUPOTON cure diseases?

    The manufacturer presents it as activating a regenerative environment from the patient's own blood. Its materials do not show proof of curing any specific disease in humans, so ask a physician for clinical evidence first.

Medical cautions

5 points • reviewed 2026-11-08

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  • This article is educational information only — not a diagnosis, prescription, or personal medical advice.
  • Outcomes vary by person, depending on age, underlying conditions, current medication, and the treating doctor's technique.
  • Consult a licensed physician and verify the clinic's licence before deciding on any treatment.
  • Some treatments (certain stem cell therapies in particular) are regulated differently by country — check Thai and Korean rules before travelling.
  • Prices, packages, and service details can change — confirm directly with the provider before paying.

Reviewed and last updated: 2026-11-08

References and sources

4 sources • every claim is traceable

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  1. 1. Korea Ministry of Food and Drug Safety (MFDS)

    https://www.mfds.go.kr/eng/index.do

  2. 2. Korea Ministry of Health and Welfare (MOHW)

    https://www.mohw.go.kr/eng/

  3. 3. PubMed medical research database (NIH)

    https://pubmed.ncbi.nlm.nih.gov/

  4. 4. Medical Korea — official info for international patients (KHIDI)

    https://www.medicalkorea.or.kr/

Browse the full reference library →

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Last updated: 2026-11-08 · This content is for information only and is not medical advice. Consult a qualified doctor before making treatment decisions.

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